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KMID : 0377619750280050497
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Korean Jungang Medical Journal
1975 Volume.28 No. 5 p.497 ~ p.505
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Effects of Total Hypophysectomy on the Endocrines in the Dog
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Abstract
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1) Utilizing microsurgical technique, subtemporal total hypophysectomy of the dog was accomplished without injury to main cerebral vessels or cerebral tissue including hypothalamus. The stalk was clipped and sectioned at a higher level, and the hypophysis was removed totally.
2) Following total hypophysectomy, their body weight was decreased tempo￢rarily, but usually recovered to the preoperative level within a week. However, the decrease of their fasting venous blood sugar was constant finding, maximamly in` the range from 22 to 34 mg%, during the period from 1 to 77 days.
3) Decrease of the number of the beta and delta cells in the Langerhans islet and increase of the granularity in the beta cell were also constant findings in these experimental animals.
4) The decrease of adrenal cortical thickness in totally hypophysectomized dogs was interpreted as a consequence of profound atrophy in the zonae fasciculata and reticularis. No significant alteration was found in the zona glomerulosa and medullary part.
5) Testicular changes in totally hypophysectomized dogs were characterized by marked reduction of the diameter of seminiferous tubules and spermatogenic activity, relative increase of Sertoli cells, mild thickening of basement membrane, and Leydig cell hyperplasia. Ovarian changes were reduction of overall size, decrease in number and size of gerrafian follicles, atrophy of follicular and cortical stromal cells, degeneration of ova and absence of corpus lutea.
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